1 Loftus PA, Wise SK. Epidemiology of asthma. Curr Opin Otolaryngol Head Neck Surg. 2016;24(3):245–9.
2 Wüthrich B. Clinical aspects, epidemiology, and prognosis of atopic dermatitis. Ann Allergy, Asthma Immunol. 1999;83(5):464–70.
3 Wüthrich B, Schmid-Grendelmeier P, Schindler C, Imboden M, Bircher A, Zemp E, et al. Prevalence of Atopy and Respiratory Allergic Diseases in the Elderly SAPALDIA Population. Int Arch Allergy Immunol. 2013;162(2):143–8.
4 Silverberg JI, Gelfand JM, Margolis DJ, Boguniewicz M, Fonacier L, Grayson MH, et al. Atopic Dermatitis in US Adults: From Population to Health Care Utilization. J Allergy Clin Immunol Pract. 2019;7(5):1524-1532.e2.
5 Bundesamt für Statistik. Bilanz der ständigen Wohnbevölkerung. 2017.
6 Mitchell AA, Gilboa SM, Werler MM, Kelley KE, Louik C, Hernández-Díaz S. Medication use during pregnancy, with particular focus on prescription drugs: 1976–2008. Am J Obstet Gynecol. 2011;205(1):51.e1-51.e8.
7 Friebe-Hoffmann U, Lindemann J. Update Schwangerschaftsrhinitis. Laryngo-Rhino-Otologie. 2018;97(07):457–64.
8 Yau W-P, Mitchell AA, Lin KJ, Werler MM, Hernández-Díaz S. Use of Decongestants During Pregnancy and the Risk of Birth Defects. Am J Epidemiol. 2013;178(2):198–208.
9 Ellegård EK. The etiology and management of pregnancy rhinitis. Am J Respir Med. 2003;2(6):469–75.
10 Somoskövi Á, Bártfai Z, Tamási L, Kocsis J, Puhó E, Czeizel AE. Population-based case-control study of allergic rhinitis during pregnancy for birth outcomes. Eur J Obstet Gynecol Reprod Biol. 2007;131(1):21–7.
11 Bruno LO, Simoes RS, de Jesus Simoes M, Girão MJBC, Grundmann O. Pregnancy and herbal medicines: An unnecessary risk for women’s health-A narrative review. Phyther Res. 2018;32(5):796–810.
12 Ahmed M, Hwang JH, Choi S, Han D. Safety classification of herbal medicines used among pregnant women in Asian countries: a systematic review. BMC Complement Altern Med. 2017;17(1):489.
13 Boivin J, Schmidt L. Use of complementary and alternative medicines associated with a 30% lower ongoing pregnancy/live birth rate during 12 months of fertility treatment. Hum Reprod. 2009;24(7):1626–31.
14 Tata LJ, Lewis SA, McKeever TM, Smith CJP, Doyle P, Smeeth L, et al. A Comprehensive Analysis of Adverse Obstetric and Pediatric Complications in Women with Asthma. Am J Respir Crit Care Med. 2007;175(10):991–7.
15 Mendola P, Laughon SK, Männistö TI, Leishear K, Reddy UM, Chen Z, et al. Obstetric complications among US women with asthma. Am J Obstet Gynecol. 2013;208(2):127.e1-127.e8.
16 Källén B, Rydhstroem H, Aberg A. Asthma during pregnancy – a population based study. Eur J Epidemiol. 2000;16(2):167–71.
17 Zetstra-van der Woude PA, Vroegop JS, Bos HJ, de Jong-van den Berg LTW. A population analysis of prescriptions for asthma medications during pregnancy. J Allergy Clin Immunol. 2013;131(3):711–7.
18 Stenius-Aarniala BS, Hedman J, Teramo KA. Acute asthma during pregnancy. Thorax. 1996;51(4):411–4.
19 Global Initiative For Asthma, Global Strategy for Asthma Management and Prevention (2018 update) [Internet]. 2018 [cited 2019 Feb 22]. Available from:
https://ginasthma.org/wp-content/uploads/2018/04/wms-GINA-2018-report-tracked_v1.3.pdf
20 Murphy V, Jensen M, Gibson P. Asthma during Pregnancy: Exacerbations, Management, and Health Outcomes for Mother and Infant. Semin Respir Crit Care Med. 2017;38(02):160–73.
21 British Thoracic Society and Scottish Intercollegiate Guidelines Network. British guideline on the management of ashtma: a national clinical guideline. [Internet]. 2016 [cited 2019 Feb 22]. Available from:
https://www.brit-thoracic.org.uk/document-library/clinical-information/asthma/btssign-asthma-guideline-2016/
22 Ambros-Rudolph CM, Müllegger RR, Vaughan-Jones SA, Kerl H, Black MM. The specific dermatoses of pregnancy revisited and reclassified: Results of a retrospective two-center study on 505 pregnant patients. J Am Acad Dermatol. 2006;54(3):395–404.
23 Vestergaard C, Wollenberg A, Barbarot S, Christen-Zaech S, Deleuran M, Spuls P, et al. European task force on atopic dermatitis position paper: treatment of parental atopic dermatitis during preconception, pregnancy and lactation period. J Eur Acad Dermatology Venereol. 2019 Jun 23;
24 Wollenberg A, Barbarot S, Bieber T, Christen-Zaech S, Deleuran M, Fink-Wagner A, et al. Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part II. J Eur Acad Dermatology Venereol. 2018;32(6):850–78.
25 Zuberbier T, Aberer W, Asero R, Abdul Latiff AH, Baker D, Ballmer-Weber B, et al. The EAACI/GA2LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria. Allergy. 2018;73(7):1393–414.
26 Spertini F, Ballmer-Weber B, Bircher AJ, Ferrari G, Grabbe J, Hausmann O, et al. Urtikariamanagement in der Grundversorgung. Swiss Med Forum. 2017;17(32):660–4.
27 Confino-Cohen R, Chodick G, Shalev V, Leshno M, Kimhi O, Goldberg A. Chronic urticaria and autoimmunity: Associations found in a large population study. J Allergy Clin Immunol. 2012 May;129(5):1307–13.
28 Maurer M, Abuzakouk M, Bérard F, Canonica W, Oude Elberink H, Giménez-Arnau A, et al. The burden of chronic spontaneous urticaria is substantial: Real-world evidence from ASSURE-CSU. Allergy. 2017;72(12):2005–16.
29 Lieberman P, Camargo CA, Bohlke K, Jick H, Miller RL, Sheikh A, et al. Epidemiology of anaphylaxis: findings of the American College of Allergy, Asthma and Immunology Epidemiology of Anaphylaxis Working Group. Ann Allergy, Asthma Immunol. 2006;97(5):596–602.
30 McCall SJ, Bunch KJ, Brocklehurst P, D’Arcy R, Hinshaw K, Kurinczuk JJ, et al. The incidence, characteristics, management and outcomes of anaphylaxis in pregnancy: a population-based descriptive study. BJOG. 2018;125(8):965–71.
31 Simons FER, Schatz M. Anaphylaxis during pregnancy. J Allergy Clin Immunol. 2012;130(3):597–606.
32 Jörg L, Steiner U, Fricker M, Helbling A. Der allergische Notfall: Adrenalin das Mittel der Wahl bei der Anaphylaxie. Z Allgemeinmed. 2013;(12).
33 Pali-Schöll I, Namazy J, Jensen-Jarolim E. Allergic diseases and asthma in pregnancy, a secondary publication. World Allergy Organ J. 2017;10:10.
34 Oykhman P, Kim HL, Ellis AK. Allergen immunotherapy in pregnancy. Allergy, Asthma Clin Immunol. 2015 Dec 10;11(1):31.
35 Amtliches Publikationsorgan der Swissmedic, Schweizerisches Heilmittelinstitut, Bern. 2003;2.
36 Swissmedic. Wegleitung für die Arzneimittelinformation für Humanarzneimittel HMV 4.
37 Swissmedic. Zulassung Humanarzneimittel nach Art. 13 HMG HMV4.
38 Brucker MC, King TL. The 2015 US Food and Drug Administration Pregnancy and Lactation Labeling Rule. J Midwifery Womens Health. 2017;62(3):308–16.
39 Kar S, Krishnan A, Preetha K, Mohankar A. A review of antihistamines used during pregnancy. J Pharmacol Pharmacother. 2012;3(2):105–8.
40 Gilboa SM, Strickland MJ, Olshan AF, Werler MM, Correa A. Use of antihistamine medications during early pregnancy and isolated major malformations. Birth Defects Res Part A Clin Mol Teratol. 2009;85(2):137–50.
41 Källén B. Use of antihistamine drugs in early pregnancy and delivery outcome. J Matern Neonatal Med. 2002;11(3):146–52.
42 Swissmedic. Arzneimittelinformation [Internet]. Available from:
http://www.swissmedicinfo.ch/
43 Gilbert C, Mazzotta P, Loebstein R, Koren G. Fetal Safety of Drugs Used in the Treatment of Allergic Rhinitis. Drug Saf. 2005;28(8):707–19.
44 Norjavaara E, de Verdier MG. Normal pregnancy outcomes in a population-based study including 2,968 pregnant women exposed to budesonide. J Allergy Clin Immunol. 2003;111(4):736–42.
45 Charlton RA, Snowball JM, Nightingale AL, Davis KJ. Safety of Fluticasone Propionate Prescribed for Asthma During Pregnancy: A UK Population-Based Cohort Study. J allergy Clin Immunol Pract. 3(5):772-9.e3.
46 Källén B, Rydhstroem H, Aberg A. Congenital malformations after the use of inhaled budesonide in early pregnancy. Obstet Gynecol. 1999;93(3):392–5.
47 Garne E, Vinkel Hansen A, Morris J, Jordan S, Klungsøyr K, Engeland A, et al. Risk of congenital anomalies after exposure to asthma medication in the first trimester of pregnancy – a cohort linkage study. BJOG. 2016;123(10):1609–18.
48 Bérard A, Sheehy O, Kurzinger M-L, Juhaeri J. Intranasal triamcinolone use during pregnancy and the risk of adverse pregnancy outcomes. J Allergy Clin Immunol. 2016;138(1):97-104.e7.
49 Gonzalez-Estrada A, Geraci SA. Allergy Medications During Pregnancy. Am J Med Sci. 2016;352(3):326–31.
50 Chi C-C, Wang S-H, Wojnarowska F, Kirtschig G, Davies E, Bennett C. Safety of topical corticosteroids in pregnancy. Cochrane Database Syst Rev. 2015 Oct 26;
51 Wollenberg A, Barbarot S, Bieber T, Christen-Zaech S, Deleuran M, Fink-Wagner A, et al. Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I. J Eur Acad Dermatology Venereol. 2018;32(5):657–82.
52 Park-Wyllie L, Mazzotta P, Pastuszak A, Moretti ME, Beique L, Hunnisett L, et al. Birth defects after maternal exposure to corticosteroids: Prospective cohort study and meta-analysis of epidemiological studies. Teratology. 2000;62(6):385–92.
53 Hviid A, Molgaard-Nielsen D. Corticosteroid use during pregnancy and risk of orofacial clefts. Can Med Assoc J. 2011 Apr;183(7):796–804.
54 Beitins IZ, Bayard F, Ances IG, Kowarski A, Migeon CJ. The transplacental passage of prednisone and prednisolone in pregnancy near term. J Pediatr. 1972;81(5):936–45.
55 Busse WW. NAEPP Expert Panel ReportManaging Asthma During Pregnancy: Recommendations for Pharmacologic Treatment—2004 Update. J Allergy Clin Immunol. 2005;115(1):34–46.
56 Lim A, Stewart K, König K, George J. Systematic Review of the Safety of Regular Preventive Asthma Medications During Pregnancy. Ann Pharmacother. 2011;45(7–8):931–45.
57 Cossette B, Beauchesne M-F, Forget A, Lemière C, Larivée P, Rey E, et al. Relative perinatal safety of salmeterol vs formoterol and fluticasone vs budesonide use during pregnancy. Ann Allergy Asthma Immunol. 2014;112(5):459–64.
58 GINA Guidelines 2019.
59 Bakhireva LN, Jones KL, Schatz M, Klonoff-Cohen HS, Johnson D, Slymen DJ, et al. Safety of leukotriene receptor antagonists in pregnancy. J Allergy Clin Immunol. 2007;119(3):618–25.
61 Namazy J, Cabana MD, Scheuerle AE, Thorp JM, Chen H, Carrigan G, et al. The Xolair Pregnancy Registry (EXPECT): The safety of omalizumab use during pregnancy. J Allergy Clin Immunol. 2015;135(2):407–12.
62 Farne HA, Wilson A, Powell C, Bax L, Milan SJ. Anti-IL5 therapies for asthma. Cochrane Database Syst Rev. 2017 Sep 21;
63 Benralizumab Pregnancy Exposure Study [Internet]. 2019 [cited 2019 Feb 22]. Available from:
https://clinicaltrials.gov/ct2/show/NCT03794999
64 Dupixent (Dupilumab) Prescribing Information [Internet]. 2017. [cited 2019 May 26]. Available from:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/761055s007lbl.pdf
65 European public assessment report (EPAR) for Dupixent [Internet]. 2017. Available from:
https://www.ema.europa.eu/en/medicines/human/EPAR/dupixent