1 Sendi P, Strahm C, Vogt M, Achermann Y, Eich G, Borens O, Clauss M, Uçkay I; pour le groupe d’experts «Infections» de Swiss Orthopaedics. Antibioprophylaxie périopératoire dans l’arthroplastie prothétique élective. Forum Med Suisse. 2022;22(1920):318–25.
2 Gosselin RA, Roberts I, Gillespie WJ. Antibiotics for preventing infection in open limb fractures. Cochrane Database Syst Rev. 2004;2004(1):CD003764.
3 Patzakis MJ, Harvey JP Jr, Ivler D. The role of antibiotics in the management of open fractures. J Bone Joint Surg Am. 1974;56(3):532–41.
4 Uçkay I, Sax H, Harbarth S, Bernard L, Pittet D. Multi-resistant infections in repatriated patients after natural disasters: lessons learned from the 2004 tsunami for hospital infection control. J Hosp Infect. 2008;68(1):1–8.
5 Dunkel N, Pittet D, Tovmirzaeva L, Suva D, Bernard L, Lew D, et al. Short duration of antibiotic prophylaxis in open fractures does not enhance risk of subsequent infection. Bone Joint J. 2013;95-B(6):831–7.
6 Roddy E, Patterson JT, Kandemir U. Delay of Antibiotic Administration Greater than 2 Hours Predicts Surgical Site Infection in Open Fractures. Injury. 2020;51(9):1999–2003.
7 Dumontier C, Lemerle J. Antibioprophylaxy in hand surgery: toward a professional consensus. Chir Main. 2004;23(4):167–77.
8 Vasenius J, Tulikoura I, Vainionpaa S, Rokkanen P. Clindamycin versus cloxacillin in the treatment of 240 open fractures. A randomized prospective study. Ann Chir Gynaecol. 1998;87(3):224–8.
9 Metcalfe D, Aquilina AL, Hedley HM. Prophylactic antibiotics in open distal phalanx fractures: systematic review and meta-analysis. J Hand Surg Eur Vol. 2016;41(4):423–30.
10 Gustilo RB. Management of open fractures. An analysis of 673 cases. Minn Med. 1971;54(3):185–9.
11 Gustilo RB AJ. Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses. J Bone Joint Surg Am. 1976;58:453–8.
12 Isaac SM, Woods A, Danial IN, Mourkus H. Antibiotic Prophylaxis in Adults With Open Tibial Fractures: What Is the Evidence for Duration of Administration? A Systematic Review. J Foot Ankle Surg. 2016;55(1):146–50.
13 Kamal A, Kanakeshwar RB, Shyam A, Jayaramaraju D, Agraharam D, Perumal R, et al. Variation in practice preferences in management of open injuries of extremities-an international survey by SICOT research academy. Int Orthop. 2017;41(1):3–11.
14 Ukai T, Hamahashi K, Uchiyama Y, Kobayashi Y, Watanabe M. Retrospective analysis of risk factors for deep infection in lower limb Gustilo-Anderson type III fractures. J Orthop Traumatol. 2020;21(1):10.
15 Brumback RJ JA. Interobserver agreement in the classification of open fractures of the tibia. The results of a survey of two hundred and forty-five orthopaedic surgeons. Bone Joint Surg Am. 1994;76(8):1162–6.
16 Khalil D, Hultin M, Rashid MU, Lund B. Oral microflora and selection of resistance after a single dose of amoxicillin. Clin Microbiol Infect. 2016;22(11):949e1–e4.
17 Wuarin L, Abbas M, Harbarth S, Waibel F, Holy D, Burkhard J, et al. Changing perioperative prophylaxis during antibiotic therapy and iterative debridement for orthopedic infections? PLoS One. 2019;14(12):e0226674.
18 Cohen ME, Salmasian H, Li J, Liu J, Zachariah P, Wright JD, et al. Surgical Antibiotic Prophylaxis and Risk for Postoperative Antibiotic-Resistant Infections. J Am Coll Surg. 2017;225(5):631–8.e3.
19 Depypere M, Morgenstern M, Kuehl R, Senneville E, Moriarty TF, Obremskey WT, et al. Pathogenesis and management of fracture-related infection. Clin Microbiol Infect. 2020;26(5):572–8.
20 Bremmer D, Bookstaver B, Cairns M, Lindley K, Durkin M, Koon D, et al. Impact of Body Mass Index and Bacterial Resistance in Osteomyelitis after Antibiotic Prophylaxis of Open Lower-Extremity Fractures. Surg Infect (Larchmt). 2017;18(3):368–73.
21 Youbong TJ, De Pontfarcy A, Rouyer M, Strazzula A, Chakvetadze C, Flateau C, et al. Bacterial Epidemiology of Surgical Site Infections after Open Fractures of the Lower Limb: A Retrospective Cohort Study. Antibiotics (Basel). 2021;10(12):1513.
22 Yusuf E, Steinrucken J, Buchegger T, Trampuz A, Borens O. A descriptive study on the surgery and the microbiology of Gustilo type III fractures in an university hospital in Switzerland. Acta Orthop Belg. 2015;81(2):327–32.
23 Roberts NJ Jr, Douglas RG Jr. Gentamicin use and Pseudomonas and Serratia resistance: effect of a surgical prophylaxis regimen. Antimicrob Agents Chemother. 1978;13(2):214–20.
24 Harbarth S, Samore MH, Lichtenberg D, Carmeli Y. Prolonged antibiotic prophylaxis after cardiovascular surgery and its effect on surgical site infections and antimicrobial resistance. Circulation. 2000;101(25):2916–21.
25 Velmahos GC, Toutouzas KG, Sarkisyan G, Chan LS, Jindal A, Karaiskakis M, et al. Severe trauma is not an excuse for prolonged antibiotic prophylaxis. Arch Surg. 2002;137(5):537–41; discussion 41–2.
26 Di Benedetto C HP, Lew D, Uçkay I. Post-traumatic septic arthritis. Eur Musculoskelet Rev 2012;7:1–5.
27 Shawar SK, Ly TV, Li J, Shirk MB, Reichert EM. Piperacillin/Tazobactam versus Tobramycin-Based Antibiotic Prophylaxis for Type III Open Fractures. Surg Infect (Larchmt). 2020;21(1):23–8.
28 Tremp M, Oranges CM, Majewski M, Schaefer DJ, Kalbermatten DF, Bloch-Infanger C, et al. Clostridial Infection After Open Fractures of the Lower Extremity - Report of Two Cases and Discussion of Pathomechanism and Treatment. In Vivo. 2020;34(1):291–8.
29 Lloyd BA, Murray CK, Bradley W, Shaikh F, Aggarwal D, Carson ML, et al. Variation in Postinjury Antibiotic Prophylaxis Patterns Over Five Years in a Combat Zone. Mil Med. 2017;182(S1):346–52.
30 Janmohammadi N, Hasanjani Roshan MR. Comparison the Efficacy of Cefazolin plus Gentamicin with Cefazolin plus Ciprofloxacin in Management of Type –IIIA Open Fractures. Iran Red Crescent Med J. 2011;13(4):239–42.
31 Redfern J, Wasilko SM, Groth ME, McMillian WD, Bartlett CS, 3rd. Surgical Site Infections in Patients With Type 3 Open Fractures: Comparing Antibiotic Prophylaxis With Cefazolin Plus Gentamicin Versus Piperacillin/Tazobactam. J Orthop Trauma. 2016;30(8):415–9.
32 Ondari JN, Masika MM, Ombachi RB, Ating’a JE. Unblinded randomized control trial on prophylactic antibiotic use in gustilo II open tibia fractures at Kenyatta National Hospital, Kenya. Injury. 2016;47(10):2288–93.
33 Mener A, Staley C, Boissonneault A, Reisman W, Schenker M, Hernandez-Irizarry R. Infection After Open Long Bone Fractures: Can We Improve on Prophylaxis? J Surg Res. 2021;268:33–9.
34 McMurtrie T, Prather J, Cone R, Montgomery T, Patel C, McGwin G, et al. Extended Antibiotic Coverage in the Management of Type II Open Fractures. Surg Infect (Larchmt). 2021;22(7):662–7.
35 Saveli CC, Morgan SJ, Belknap RW, Ross E, Stahel PF, Chaus GW, et al. Prophylactic antibiotics in open fractures: a pilot randomized clinical safety study. J Orthop Trauma. 2013;27(10):552–7.
36 Takahara S, Tokura T, Nishida R, Uefuji A, Ichimura K, Nishihara H, et al. Ampicillin/sulbactam versus cefazolin plus aminoglycosides for antimicrobial prophylaxis in management of Gustilo type IIIA open fractures: A retrospective cohort study. Injury. 2022;53(4):1517–22.
37 Depcinski SC, Nguyen KH, Ender PT. Cefazolin and an aminoglycoside compared with cefazolin alone for the antimicrobial prophylaxis of type III open orthopedic fractures. Int J Crit Illn Inj Sci. 2019;9(3):127–31.
38 Patanwala AE RJ, Meshay I, Naderi M, Culver MA, Lee YG, Weinberg JA, Khobrani M, Nix DE. Cefazolin Monotherapy Versus Cefazolin Plus Aminoglycosides for Antimicrobial Prophylaxis of Type III Open Fractures. Am J Ther. 2019;28(3):284–91.
39 Bankhead-Kendall B, Gutierrez T, Murry J, Holland D, Agrawal V, Almahmoud K, et al. Antibiotics and open fractures of the lower extremity: less is more. Eur J Trauma Emerg Surg. 2019;45(1):125–9.
40 Gonzalez A, Suvà D, Dunkel N, Nicodeme JD, Lomessy A, Lauper N, et al. Are there clinical variables determining antibiotic prophylaxis-susceptible versus resistant infection in open fractures? Int Orthop. 2014;38(11):2323–7.
41 Puetzler J, Zalavras C, Moriarty TF, Verhofstad MHJ, Kates SL, Raschke MJ, et al. Clinical practice in prevention of fracture-related infection: An international survey among 1197 orthopaedic trauma surgeons. Injury. 2019;50(6):1208–15.
42 Barton CA, McMillian WD, Crookes BA, Osler T, Bartlett CS, 3rd. Compliance with the Eastern Association for the Surgery of Trauma guidelines for prophylactic antibiotics after open extremity fracture. Int J Crit Illn Inj Sci. 2012;2(2):57–62.
43 Johnson HC, Bailey AM, Baum RA, Justice SB, Weant KA. Compliance and Related Outcomes of Prophylactic Antibiotics in Traumatic Open Fractures. Hosp Pharm. 2020;55(3):193–8.
44 Endres T, Danielson K, O’Neil S, Brandenburg S, Hall T, Ross H. Implementation of an Antibiotic Therapy Protocol for Open Fractures in the Emergency Department. Spartan Med Res J. 2018;3(2):6898.
45 Lebowitz D, Kressmann B, Gjoni S, Zenelaj B, Grosgurin O, Marti C, et al. Clinical features of anaerobic orthopaedic infections. Infect Dis (Lond). 2017;49(2):137–40.
46 Uçkay I, Pires D, Agostinho A, Guanziroli N, Ozturk M, Bartolone P, et al. Enterococci in orthopaedic infections: Who is at risk getting infected? J Infect. 2017;75(4):309–14.
47 Rine NI MP, Schrickel TT, Drew S, Gemmel DJ, Donley CW, Lauver AR. Noninferiority Comparison of Prophylactic Open Fracture Antimicrobial Regimens. 2020. ClinicalTrials.gov Identifier: NCT03560232.
48 Hasler A, Unterfrauner I, Olthof MGL, Jans P, Betz M, Achermann Y, et al. Deep surgical site infections following double-dose perioperative antibiotic prophylaxis in adult obese orthopedic patients. Int J Infect Dis. 2021;108:537–42.
49 Chang Y, Bhandari M, Zhu KL, Mirza RD, Ren M, Kennedy SA, et al. Antibiotic Prophylaxis in the Management of Open Fractures: A Systematic Survey of Current Practice and Recommendations. JBJS Rev. 2019;7(2):e1.
50 Olinger CR, Carver DC, Nolan VG, Weinlein JC. The Effect of Under-Dosing Prophylactic Antibiotics in the Care of Open Tibial Fractures. J Orthop Trauma. 2018;32(7):322–6.
51 Pinto D, Manjunatha K, Savur AD, Ahmed NR, Mallya S, Ramya V. Comparative study of the efficacy of gentamicin-coated intramedullary interlocking nail versus regular intramedullary interlocking nail in Gustilo type I and II open tibia fractures. Chin J Traumatol. 2019;22(5):270–3.
52 Kim EK, Donnelley CA, Tiee M, Roberts HJ, Von Kaeppler E, Shearer D, et al. Prophylactic Topical Antibiotics in Fracture Repair and Spinal Fusion. Adv Orthop. 2021;2021:1949877.
53 Craig J, Fuchs T, Jenks M, Fleetwood K, Franz D, Iff J, et al. Systematic review and meta-analysis of the additional benefit of local prophylactic antibiotic therapy for infection rates in open tibia fractures treated with intramedullary nailing. Int Orthop. 2014;38(5):1025–30.
54 Morgenstern M, Vallejo A, McNally MA, Moriarty TF, Ferguson JY, Nijs S, et al. The effect of local antibiotic prophylaxis when treating open limb fractures: A systematic review and meta-analysis. Bone Joint Res. 2018;7(7):447–56.
55 Franz D, Raschke M, Giannoudis PV, Leliveld M, Metsemakers WJ, Verhofstad MHJ, et al. Use of antibiotic coated intramedullary nails in open tibia fractures: A European medical resource use and cost-effectiveness analysis. Injury. 2021;52(7):1951–8.
56 Moehring HD GC, Chapman MW, Olson SA. Comparison of antibiotic beads and intravenous antibiotics in open fractures. Clinical Trial Clin Orthop Relat Res. 2000;372:254–61.
57 Lawing CR, Lin FC, Dahners LE. Local Injection of Aminoglycosides for Prophylaxis Against Infection in Open Fractures. J Bone Joint Surg Am. 2015;97(22):1844–51.
58 Greco T, Cianni L, Polichetti C, Inverso M, Maccauro G, Perisano C. Uncoated vs. Antibiotic-Coated Tibia Nail in Open Diaphyseal Tibial Fracture (42 according to AO Classification): A Single Center Experience. Biomed Res Int. 2021;2021:7421582.
59 Hoff, WS, Bonadies JA, Cachecho R, Dorlac WC. East Practice Management Guidelines Work Group: update to practice management guidelines for prophylactic antibiotic use in open fractures. J Trauma. 2011:7(3):751–4.
60 Nanchahal J, Nayagam S, Khan U, Moran C, Barret S, Sanderson F, Pallister I. Standard for the management of Open Fractures of the Lower Limb. British Association of Plastic, Reconstructive and Aesthetic Surgeons (BAPRAS). 2009;1–108. Available under: https://www.bapras.org.uk/docs/default-source/commissioning-and-policy/standards-for-lower-limb.pdf?sfvrsn=0 [last assessed 2022 May 23].
61 Messner J, Papakostidis C, Giannoudis PV, Kanakaris NK. Duration of Administration of Antibiotic Agents for Open Fractures: Meta-Analysis of the Existing Evidence. Surg Infect (Larchmt). 2017;18(8):854–67.
62 Stevenson J, McNaughton G, Riley J. The use of prophylactic flucloxacillin in treatment of open fractures of the distal phalanx within an accident and emergency department: a double-blind randomized placebo-controlled trial. J Hand Surg Br. 2003;28(5):388–94.
63 Suprock MD HJ, Lubahn JD. Role of antibiotics in open fractures of the finger. J Hand Surg Am. 1990;15(5):761–4.
64 Declercq P, Zalavras C, Nijssen A, Mertens B, Mesure J, Quintens J, et al. Impact of duration of perioperative antibiotic prophylaxis on development of fracture-related infection in open fractures. Arch Orthop Trauma Surg. 2021;141(2):235–43.
65 Dellinger EP, Caplan ES, Weaver LD, Wertz MJ, Droppert BM, Hoyt N, et al. Duration of preventive antibiotic administration for open extremity fractures. Arch Surg. 1988;123(3):333–9.
66 Peacock KC HD, Kirkpatrick K, Breidenbach WC, Lister GD, Firrell J. Efficacy of perioperative cefamandole with postoperative cephalexin in the primary outpatient treatment of open wounds of the hand. J Hand Surg Am. 1998;13(6):960–4.
67 Lack W, Seymour R, Bickers A, Studnek J, Karunakar M. Prehospital Antibiotic Prophylaxis for Open Fractures: Practicality and Safety. Prehosp Emerg Care. 2019;23(3):385–8.
68 Whitehouse MR, McDaid C, Kelly MB, Moran CG, Costa ML. The effect of timing of antibiotic delivery on infection rates related to open limb fractures: a systematic review. Emerg Med J. 2017;34(9):613–20.
69 Al-Arabi YB, Nader M, Hamidian-Jahromi AR, Woods DA. The effect of the timing of antibiotics and surgical treatment on infection rates in open long-bone fractures: a 9-year prospective study from a district general hospital. Injury. 2007;38(8):900–5.
70 Manjyra M, Basson T, Du Preez G, Du Toit G, Ferreira N. Current concepts in the management of open tibia fractures. SA Orthop J. 2019;18(4):52–62.
71 Albright PD, MacKechnie MC, Roberts HJ, Shearer DW, Padilla Rojas LG, Segovia J, et al. Open Tibial Shaft Fractures: Treatment Patterns in Latin America. J Bone Joint Surg Am. 2020;102(22):126.
72 Zuelzer DA HC, Hautala GS, Akbar A, Mayer RR, Jacobs CA, Wright RD, Moghadamian ES, Matuszewski PE. Early Antibiotic Administration Is Associated with a Reduced Infection Risk When Combined with Primary Wound Closure in Patients with Open Tibia Fractures. Clin Orthop Relat Res 2021;479(3):613–9.
73 Goodman AD, Modest JM, Johnson JP, Hayda RA. A Simple Initiative to Decrease Time to Antibiotic Prophylaxis for Open Fractures Is Durable After 2 Years. J Am Acad Orthop Surg. 2021;29(18):e932–e9.
74 Kohlprath R, Assal M, Uçkay I, Holzer N, Hoffmeyer P, Suva D. Open fractures of the tibia in the adult: surgical treatment and complications. Rev Med Suisse. 2011;7(322):2482, 2484-8.
75 Olesen UK, Juul R, Bonde CT, Moser C, McNally M, Jensen LT, et al. A review of forty-five open tibial fractures covered with free flaps. Analysis of complications, microbiology and prognostic factors. Int Orthop. 2015;39(6):1159–66.
76 Bhandari M, Petrisor BA, Jeray KJ. Wound Irrigation in Initial Management of Open Fractures. N Engl J Med. 2016;374(18):1789–90.
77 Anglen JO. Comparison of soap and antibiotic solutions for irrigation of lower-limb open fracture wounds. A prospective, randomized study. J Bone Joint Surg Am. 2005;87(7):1415–22.
78 Hauser CJ, Adams CA, Jr., Eachempati SR, Council of the Surgical Infection Society guideline: prophylactic antibiotic use in open fractures: an evidence-based guideline. Surg Infect (Larchmt). 2006;7(4):379–405.